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Updated: May 6, 2026
Co-culture of Glutamatergic Neurons and Pediatric High-Grade Glioma Cells Into Microfluidic Devices to Assess Electrical Interactions
Published on: November 17, 2021
Neuroblastoma cells as possible model in the study of glutamate receptors
J B van der Valk1, H P Vijverberg
1Research Institute of Toxicology, University of Utrecht, P.O. Box 80.176, NL-3508, Utrecht, TD, The Netherlands.
Abstract:
The sensitivity of several cultured neuroblastoma cell lines toL-glutamate (Glu) and its analogues has been studied with the whole-cell patch clamp technique. Only in the neuroblastoma cell line N2A Glu induced a concentration dependent response consisting of an inward current. In addition, N2A cells responded to superfusion with kainate, quisqualate orN-methyl-D-aspartate, but to a lesser degree than to Glu. It is concluded that N2A cells could be useful as anin vitro model to study excitatory amino acid properties.
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