Related Experiment Video
Updated: May 6, 2026

Measurement of Cellular Chemotaxis with ECIS/Taxis
Published on: April 1, 2012
Antigen-induced eosinophil chemotactic factor (ECF) release by human leukocytes
B M Czarnetzki1, W König, L M Lichtenstein
1Clinical Immunology Division, The Johns Hopkins University School of Medicine at The Good Samaritan Hospital, 5601 Loch Raven Boulevard, Baltimore, Maryland.
Abstract:
A complement-independent eosinophil chemotactic factor (ECF) is described which is released from peripheral leukocytes of allergic and normal human volunteers after antigen stimulation and after exposure to anti-IgE. Dose response and time-release curves for ECF and histamine run closely parallel in this system. Histamine by itself is shown to have no effect on chemotaxis at the concentrations present in antigen-induced release, but is inhibitory at very high concentrations. Evidence suggests that the ECF released from human leukocytes is derived from basophils and is similar, or identical, to the ECF released from mast cells.
More Related Videos
Related Concept Videos
Chemotaxis and Direction of Cell Migration
Chemotaxis in E. coli
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Asthma I: Introduction
Allergic Reactions

