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Induction of abundant antibody formation with a protein-cellulose complex in mice

A E Gurvich, A Korukova

    Journal of Immunological Methods
    |March 13, 1986
    PubMed

    A method is described for immunizing mice with a protein-cellulose complex obtained by covalent coupling of antigenic protein molecules to suspended cellulose particles. Primary immunization of the animals with the complex led to a pronounced immune response persisting for 20-30 days. Subsequent administration of the same antigen in a soluble form resulted in extremely active antibody formation equal to or better than that induced with Freund's complete adjuvant. In BALB/c mice the antibody response was about ten times greater than in the C57BL/6 strain.

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