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Updated: May 6, 2026
Lumican Extraction from Amniotic Membrane and Determination of its Storage Temperature
Published on: October 14, 2022
Association between lumican gene -1554 T/C polymorphism and high myopia in Asian population: a meta-analysis
Xuan Liao1, Xu-Bo Yang, Meng Liao
1Department of Ophthalmology, West China School of Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China ; Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong 637007, Sichuan Province, China.
Aim:
To investigate the association between lumican gene -1554 T/C polymorphism and high myopia susceptibility.
Methods:
We searched the published literature in the Medline, Embase, and CBM databases from inception to July 2013. A meta-analysis was performed by the programs RevMan 5.1 and Stata 12.0, and the odds ratio (OR) with 95% confidence interval (CI) was calculated in fixed or random effect model based on heterogeneity test among studies.
Resluts:
Seven case-control studies with a total of 1 233 cases and 936 controls were included. A statistical significant association with high myopia was observed in the recessive model (TT vs CT+CC: OR=1.92; 95%CI=1.14-3.23) and codominant model (TT vs CT: OR=1.81, 95%CI=1.19-2.75).
Conclusion:
The present meta-analysis suggested that lumican -1554 T/C polymorphism might be moderately associated with high myopia susceptibility. This conclusion warrants confirmation by further studies.
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