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Precision Measurements and Parametric Models of Vertebral Endplates
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Proteinticle engineering for accurate 3D diagnosis.

Jong-Hwan Lee1, Hyuk Seong Seo, Jong Am Song

  • 1Department of Chemical and Biological Engineering, College of Engineering, Korea University , Anam-Ro 145, Seoul 136-713, Republic of Korea.

ACS Nano
|November 8, 2013
PubMed
Summary

Engineered protein nanoparticles (proteinticles) can detect disease-specific antibodies for accurate diagnosis. This novel approach enables sensitive and specific detection of autoimmune and infectious diseases like multiple sclerosis and hepatitis C.

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Area of Science:

  • Biotechnology
  • Nanomedicine
  • Immunology

Background:

  • Proteins self-assemble into nanoscale particles (proteinticles) with defined structures.
  • Proteinticles offer advantages over synthetic nanomaterials due to facile genetic modification for surface functionalization.

Purpose of the Study:

  • To engineer human ferritin-based proteinticles displaying disease-specific antibodies for accurate diagnostics.
  • To develop proteinticle-based assays for diagnosing autoimmune and infectious diseases.

Main Methods:

  • Genetically modified human ferritin to display specific proteins/peptides on the proteinticle surface.
  • Engineered proteinticles to display the extracellular domain of myelin oligodendrocyte glycoprotein (MOG) for multiple sclerosis diagnosis.
  • Created heterogeneous proteinticles displaying multiple antigenic peptides from hepatitis C virus (HCV) for HCV diagnosis.

Main Results:

  • MOG-displaying proteinticles accurately discriminated between autoantibodies to native or denatured MOG, enabling reliable multiple sclerosis diagnosis.
  • Heterogeneous proteinticles detected anti-HCV antibodies in patient sera with 100% accuracy.
  • Demonstrated the potential for sensitive and specific diagnosis of various human diseases.

Conclusions:

  • Proteinticle engineering provides a versatile platform for developing diagnostic tools.
  • This method facilitates accurate 3D diagnosis of autoimmune and infectious diseases.
  • The approach is broadly applicable to the sensitive and specific diagnosis of numerous other human diseases.