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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Gut microbiome and metabolic diseases.
1Institute for Advanced Biosciences, Keio University, 246-2 Mizukami, Kakuganji, Tsuruoka, Yamagata, 997-0052, Japan.
Seminars in Immunopathology
|November 8, 2013
Summary
The gut microbiota influences obesity and metabolic syndrome. This review explores its role and the potential of probiotics and prebiotics for combating obesity.
Area of Science:
- Microbiology
- Metabolic Science
- Nutritional Science
Background:
- Rising global obesity rates highlight the need to understand contributing factors.
- The gut microbiota is increasingly recognized for its role in obesity and metabolic syndrome.
- Microbiota alterations, favoring energy harvest, correlate with obesity.
Purpose of the Study:
- To review the complex relationship between gut microbiota and obesity.
- To elucidate the molecular mechanisms linking gut microbiota to host metabolism.
- To discuss the therapeutic potential of probiotics and prebiotics in obesity management.
Main Methods:
- Literature review of studies on gut microbiota and obesity.
- Analysis of molecular mechanisms involved in microbiota-host metabolic interactions.
- Evaluation of research on probiotics and prebiotics for anti-obesity effects.
Main Results:
- Gut microbiota composition and function are significantly altered in obesity.
- Specific microbial metabolites and pathways are implicated in host energy balance.
- Probiotics and prebiotics show promise in modulating gut microbiota and improving metabolic health.
Conclusions:
- The gut microbiota plays a critical role in obesity development and progression.
- Understanding microbiota-host interactions is key to developing novel obesity treatments.
- Probiotics and prebiotics represent viable strategies for obesity prevention and management.
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