The Relationships Between Poor Sleep Efficiency and Mild Cognitive Impairment in Parkinson Disease
David G Gunn1, Sharon L Naismith1, Zoe Terpening1
1Parkinson's Disease Research Clinic, Aging Brain Centre, Brain & Mind Research Institute, The University of Sydney, Sydney, New South Wales, Australia.
Background:
Mild cognitive impairment (MCI) and sleep disturbances are common features in Parkinson disease (PD). This study sought to investigate whether patients with MCI in PD (PD-MCI) have more pronounced sleep disturbance compared to those without PD-MCI and whether phenotypic presentations differ according to the PD-MCI subtypes.
Methods:
A total of 95 patients with idiopathic PD (53 meeting criteria for PD-MCI and 42 who were not cognitively impaired) and 22 controls underwent neurological and neuropsychological examination. They wore actigraphy watches for 2 weeks, from which measures of nocturnal sleep efficiency were calculated.
Results:
Patients with PD-MCI has significantly poorer sleep efficiency compared to those without PD-MCI. This effect was particularly apparent in those with multiple-domain PD-MCI, compared to those with single-domain PD-MCI. Furthermore, patients in the PD-MCI group had significantly more nontremor features.
Conclusions:
These data suggest that PD-MCI is associated with greater sleep disturbance and nontremor features of PD. This is further evidence for the potential role that sleep disturbance plays in the heterogeneity of PD.
Insights
Parkinson disease patients with mild cognitive impairment (PD-MCI) experience worse sleep efficiency and more non-tremor symptoms. This highlights sleep disturbance
Area of Science:
- Neurology
- Sleep Medicine
- Cognitive Neuroscience
Background:
- Parkinson disease (PD) frequently involves mild cognitive impairment (MCI) and sleep disturbances.
- Investigating the relationship between PD-MCI and sleep quality is crucial for understanding PD heterogeneity.
Purpose of the Study:
- To compare sleep disturbances in patients with PD and MCI (PD-MCI) versus those without cognitive impairment.
- To examine if PD-MCI subtypes exhibit different sleep patterns and phenotypic presentations.
Main Methods:
- 95 idiopathic PD patients (53 with PD-MCI, 42 without cognitive impairment) and 22 controls underwent assessments.
- Actigraphy watches were used for 2 weeks to measure nocturnal sleep efficiency.
Main Results:
- PD-MCI patients demonstrated significantly poorer sleep efficiency than non-MCI PD patients.
- Multiple-domain PD-MCI showed more pronounced sleep impairment compared to single-domain PD-MCI.
- PD-MCI group exhibited a higher prevalence of non-tremor features.
Conclusions:
- PD-MCI is linked to increased sleep disturbance and non-tremor symptoms in Parkinson disease.
- Sleep disturbance may contribute to the diverse clinical presentations observed in PD.
Related Concept Videos
01:24Parkinson Disease l: Introduction
01:24Parkinson Disease ll: Pathophysiology
01:24Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
01:13Insufficient Sleep and Sleep Deprivation
Sleep deprivation is a more severe form of sleep loss...
01:15Parkinson's Disease: Overview
01:11Alterations in Muscle Tone lll