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Related Experiment Video

Updated: May 6, 2026

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies

Published on: October 7, 2021

Neurosarcoidosis presenting as mononeuritis multiplex.

Ryan Mattie¹, Robert W Irwin

¹From the Division of Physical Medicine & Rehabilitation, Stanford University Department of Orthopaedic Surgery (RM); and University of Miami Leonard M. Miller School of Medicine, Florida (RWI).

American Journal of Physical Medicine & Rehabilitation

|November 8, 2013

Summary

Neurosarcoidosis can initially present as mononeuritis multiplex, affecting nerves like the ulnar and radial. Early diagnosis and treatment are crucial to prevent disease progression in patients with this rare neurological manifestation.

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Area of Science:

Neurology
Immunology

Background:

Sarcoidosis is a multisystem granulomatous disease with unknown causes.
Neurosarcoidosis affects up to 5% of patients, often presenting as the first sign of the disease.

Observation:

A case study details a patient initially presenting with mononeuritis multiplex affecting the ulnar and radial nerves.
The neurological symptoms emerged 8 months prior to the sarcoidosis diagnosis.

Findings:

Mononeuritis multiplex, particularly when idiopathic, should prompt consideration of neurosarcoidosis.
This case highlights the potential for neurosarcoidosis to manifest initially with isolated peripheral nerve involvement.

Implications:

Including neurosarcoidosis in the differential diagnosis for mononeuritis multiplex is essential.
Timely diagnosis and treatment of neurosarcoidosis can prevent further neurological damage and disease progression.