Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

865
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
865
Multiple Allele Traits01:49

Multiple Allele Traits

32.8K
The Concept of Multiple Allelism
32.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Empowering patients with high myopia: The significance of education.

Acta ophthalmologica·2023
Same author

Partial resistance to late blight (Phytophthora infestans) in hybrid progenies of four South American Solanum species crossed with diploid S. tuberosum.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Genotype-by-environment interaction in genetic mapping of multiple quantitative trait loci.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·2013
Same author

Analysis of human serum by liquid chromatography-mass spectrometry: improved sample preparation and data analysis.

Journal of chromatography. A·2006
Same author

Genetic association studies in complex disease: disentangling additional predisposing loci from associated neutral loci using a constrained - permutation approach.

Annals of human genetics·2005
Same author

Using complex plant pedigrees to map valuable genes.

Trends in plant science·2001

Related Experiment Video

Updated: May 6, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
08:27

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

4.6K

A general mixture model for mapping quantitative trait loci by using molecular markers.

R C Jansen1

  • 1Centre for Plant Breeding and Reproduction Research (CPRO-DLO), P.O. Box 16, 6700 AA, Wageningen, The Netherlands.

TAG. Theoretical and Applied Genetics. Theoretische Und Angewandte Genetik
|November 8, 2013
PubMed
Summary
This summary is machine-generated.

This study introduces a flexible mixture model for mapping quantitative trait loci (QTLs) using molecular markers. The model enhances genetic analysis by accommodating diverse trait distributions and reducing environmental and genotypic variations.

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

9.2K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K

Related Experiment Videos

Last Updated: May 6, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
08:27

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

4.6K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

9.2K
An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
10:17

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

23.3K

Area of Science:

  • Genetics
  • Statistical Genetics
  • Bioinformatics

Background:

  • Quantitative traits in segregating populations often exhibit complex distributions.
  • Mendelian segregation rules influence trait variation.
  • Existing models may not fully capture the nuances of quantitative trait loci (QTLs) mapping.

Purpose of the Study:

  • To propose a general and flexible mixture model for QTL mapping.
  • To develop a method for fitting this model to diverse biological data.
  • To enhance the analysis of quantitative traits and genetic variation.

Main Methods:

  • Utilizing a mixture model approach based on Mendelian segregation.
  • Incorporating molecular markers for trait loci detection.
  • Employing statistical methods for model fitting and analysis.

Main Results:

  • The model accommodates non-normally distributed traits (lifetimes, counts, percentages).
  • It accounts for experimental design factors and genotype-environment interactions to reduce variation.
  • Simultaneous analysis of multiple QTLs and different population types is enabled.
  • Handles missing marker data and uses markers as covariables.

Conclusions:

  • The proposed mixture model offers a robust and versatile framework for QTL mapping.
  • It improves the analysis of complex traits by integrating genetic and environmental factors.
  • The method is implementable in standard statistical packages, facilitating broader application.