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Updated: May 6, 2026

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
Published on: June 15, 2018
Clinical comparison of Simplexa universal direct and BD GeneOhm tests for detection of toxigenic Clostridium
Frederick S Nolte1, Danielle G Ribeiro-Nesbitt
1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Abstract:
We compared the performance characteristics of the Simplexa universal direct (Focus Diagnostics, Cypress, CA) and BD GeneOhm (BD Diagnostics/GeneOhm Sciences, San Diego, CA) tests for detection of toxigenic Clostridium difficile in 459 stool samples (9.4% positive). The observed agreement for the results of the two tests with 452 samples with valid test results was 98.2% (kappa, 0.9; P value of 0.73 by the McNemar test). When samples with discordant or invalid results were retested, the agreement increased to 100%.
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