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Investigating axonal guidance with microdevice-based approaches.

Isabelle Dupin1, Maxime Dahan, Vincent Studer

  • 1Université de Bordeaux, Interdisciplinary Institute for Neuroscience, Unité Mixte de Recherche 5297, F-33000 Bordeaux, France, Centre National de la Recherche Scientifique, Interdisciplinary Institute for Neuroscience, Unité Mixte de Recherche 5297, F-33000 Bordeaux, France, and Laboratoire Physico-Chimie, Institut Curie, Centre National de la Recherche Scientifique-Unité Mixte de Recherche 168, Université Pierre et Marie Curie-Paris 6, 75248 Paris Cedex 05, France.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 8, 2013
PubMed
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Microdevices offer precise control over neuronal environments, advancing the study of axon guidance. These tools enable detailed investigation into how nerve cells sense and respond to directional signals.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Biotechnology

Background:

  • Axon guidance is crucial for nervous system wiring, involving navigation through complex environments influenced by attractive and repulsive cues.
  • Studying axon guidance requires precise control over the spatiotemporal microenvironment of neurons.
  • Microfabrication techniques offer advanced control over cellular microenvironments but have specific challenges for neuronal cultures.

Purpose of the Study:

  • To review microdevices developed for studying axon guidance.
  • To compare microdevices with conventional gradient sensing assays.
  • To discuss the potential of microdevice-based approaches for investigating systems-level questions in nerve cell gradient sensing.

Main Methods:

  • Review of existing microdevices designed for axon guidance research.

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  • Comparison of microdevice capabilities with traditional cell biology gradient sensing assays.
  • Discussion of innovative microdevice applications for neuronal studies.

    • Main Results:

    • Microdevices provide unprecedented control over neuronal microenvironments, crucial for axon guidance research.
    • These devices address limitations of conventional assays in studying complex neuronal guidance mechanisms.
    • Microtechnology facilitates the investigation of neuronal sensitivity, robustness, and combinatorial responses to guidance cues.

    Conclusions:

    • Microdevices are essential tools for advancing the understanding of axon guidance mechanisms.
    • Innovative microdevice-based approaches will enable deeper insights into nerve cell gradient sensing.
    • Future research can leverage microtechnology to explore complex neuronal navigation and wiring processes.