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Effects of AV sequential versus asynchronous AV pacing on pulmonary hemodynamics
Pacing and Clinical Electrophysiology : PACE
|March 1, 1986
Summary
Altering pacemaker settings in dogs with heart block significantly impacts cardiac function and gas exchange. Ventriculo-atrial pacing (VA100) reduced cardiac output and increased oxygen levels in the lungs, affecting blood gas levels.
Area of Science:
- Cardiology
- Pulmonary Physiology
- Medical Devices
Background:
- Chronic heart block impairs cardiac function and can necessitate pacing.
- Understanding the hemodynamic and respiratory effects of different pacing modes is crucial for patient management.
Purpose of the Study:
- To investigate the impact of various pacing modes on cardiac hemodynamics and pulmonary gas exchange in dogs with chronic heart block.
Main Methods:
- Dogs with chronic heart block were subjected to different pacing modes: atrioventricular interval of 100 ms (AV100), ventriculo-atrial interval of 100 ms (VA100), and asynchronous ventricular pacing.
- Cardiac output, left ventricular pressure, and pulmonary gas exchange parameters (e.g., alveolar-arterial O2 gradient, arterial CO2 tension, minute volume of O2, end-expiratory O2 and CO2) were measured.
Main Results:
- Switching from AV100 to VA100 pacing significantly decreased left ventricular pressure and cardiac output.
- VA100 pacing increased the alveolar-arterial O2 gradient and decreased arterial CO2 tension compared to AV100.
- Minute volume of O2 and percent of expired CO2 decreased with VA100 and asynchronous ventricular pacing compared to AV100.
Conclusions:
- Pacing mode significantly influences cardiac hemodynamics and pulmonary gas exchange in heart-blocked dogs.
- Ventriculo-atrial pacing (VA100) adversely affects cardiac output and alters gas exchange dynamics, warranting careful consideration in clinical practice.