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Subset specification of central serotonergic neurons
Marten P Smidt1, Johannes A van Hooft
1Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam Amsterdam, Netherlands.
Frontiers in Cellular Neuroscience
|November 8, 2013
Summary
The serotonin (5-hydroxytryptamine; 5-HT) system
Area of Science:
- Neuroscience
- Developmental Biology
- Molecular Biology
Background:
- The serotonin (5-hydroxytryptamine; 5-HT) system is crucial for behavior regulation.
- Increased central nervous system 5-HT tone can alleviate affective disorders.
Purpose of the Study:
- To review the developmental processes of the 5-HT system in the brain.
- To emphasize subset specification in the formation of 5-HT neuronal groups.
Main Methods:
- Molecular classification of 5-HT neuronal groups.
- Analysis of selective gene expression, such as the 5-HT1A autoreceptor.
Main Results:
- Defined two rostral 5-HT neuronal groups (rhombomere 1 and 2/3) and a caudal group (rhombomere 5-8).
- Identified functional diversity among 5-HT subsets indicated by selective 5-HT1A autoreceptor expression.
Conclusions:
- Functional significance of molecular differences and connectivity patterns require further elucidation.
- Genetic lineage tracing models are essential for understanding developmental programming and function of 5-HT neuronal subsets.
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