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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
Published on: June 26, 2020
Hepatitis delta virus: a peculiar virus
Carolina Alves1, Cristina Branco, Celso Cunha
1Medical Microbiology Unit, Center for Malaria and Tropical Diseases, Institute of Hygiene and Tropical Medicine, Nova University, Rua da Junqueira 100, 1349-008 Lisbon, Portugal.
Abstract:
The hepatitis delta virus (HDV) is distributed worldwide and related to the most severe form of viral hepatitis. HDV is a satellite RNA virus dependent on hepatitis B surface antigens to assemble its envelope and thus form new virions and propagate infection. HDV has a small 1.7 Kb genome making it the smallest known human virus. This deceivingly simple virus has unique biological features and many aspects of its life cycle remain elusive. The present review endeavors to gather the available information on HDV epidemiology and clinical features as well as HDV biology.
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