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Related Experiment Videos

Chorionic villi sampling changes maternal serum alpha-fetoprotein.

F G Mariona, R Bhatia, F N Syner

    Prenatal Diagnosis
    |January 1, 1986
    PubMed
    Summary
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    Second trimester amniocentesis and chorionic villi sampling (CVS) are prenatal diagnostic methods. Detecting fetomaternal bleed (FMB) after CVS using maternal serum alpha-fetoprotein (MSAFP) levels can help assess risks.

    Area of Science:

    • Perinatology
    • Prenatal Diagnostics
    • Maternal-Fetal Medicine

    Background:

    • Amniocentesis is a traditional method for second-trimester prenatal genetic diagnosis.
    • Chorionic villi sampling (CVS) is an alternative prenatal diagnostic procedure.
    • Fetomaternal bleed (FMB) is a potential complication of CVS.

    Purpose of the Study:

    • To evaluate the significance of fetomaternal bleed (FMB) during chorionic villi sampling (CVS).
    • To explore the association between FMB and increased risk of post-sampling abortion.
    • To assess the relevance of FMB in isoimmunization-risk patients.

    Main Methods:

    • Maternal serum alpha-fetoprotein (MSAFP) levels were measured before and after CVS.
    • Changes in MSAFP were used to detect and quantify FMB.

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    Main Results:

    • The study focused on the detection and quantitation of FMB post-CVS.
    • MSAFP changes were utilized as a method for FMB assessment.

    Conclusions:

    • Detection of FMB via MSAFP monitoring is feasible after CVS.
    • This method may aid in managing risks associated with CVS, including abortion and isoimmunization.