[Preliminary study on pelvic organ prolapse treated by using small intestinal submucosa mesh]

To study clinical efficacy of porcine-derived small intestinal submucosa (Surgisis) in treatment of pelvic organ prolapse (POP).

From Mar. 2012 to Mar. 2013, 15 patients with POP at more than III of POP quantitation (POP-Q) staging system undergoing pelvic reconstructive surgery with Surgisis in Peking University People's Hospital. The mean age was 59 years old (39-82). The variable site of POP-Q staging system was compared between preoperative and postoperative status among those patients.Quality of life questionnaire of pelvic floor impact questionnaire (PFIQ-7), pelvic floor distress inventory short form (PFDI-20) and PISQ-31 were studied to evaluate subjective satisfaction, recurrence and the quality of life's improvement.

All patients were followed up at mean of 9.9 months (3-15 months), the mean time of surgery was 96 mins (65-120 mins), the mean blood loss was 159 ml (50-500 ml).No infection and erosion was observed on those patients. The rate of subjective satisfaction was 14/15, the recurrence rate of prolapse was 2/15.Scoring system of PFDI-20 was from 87 (56-124) at operative status to 30 (22-48) at postoperative status. PFIQ-20 was from 129 (85-158) at preoperative status to 24 (18-48) at postoperative status. PISQ-31 was from 48 (32-55) at preoperative status to 79 (66-89) at postoperative status, which all reached statistical difference (all P < 0.05). Total 9 patients obtained satisfactory sexual life.

The short-term clinical effect of pelvic reconstructive surgery with Surgisis was satisfied, quality of life and sexual life was improved, and less complication were observed. However, long-term clinical effect on patients should be warranted to follow up.