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Improving the predictive value of interferon-gamma release assays: do our methods go far enough?

Sandra V Kik1, Molebogeng X Rangaka

  • 1McGill International TB Centre & Department of Epidemiology & Biostatistics, McGill University, Montreal, QC, Canada.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|November 9, 2013
PubMed
Summary

No abstract available in PubMed .

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Inhibitors of Viral Protein Synthesis01:30

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Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
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