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Antipsychotics' effects on blood levels of cytokines in schizophrenia: a meta-analysis
Valérie Tourjman1, Édouard Kouassi, Marie-Ève Koué
1Centre de recherche de l'Institut Universitaire en Santé Mentale de Montréal, Montreal, Canada; Department of Psychiatry, Faculty of Medicine, University of Montreal, Montreal, Canada.
Objectives:
Evidence-based medicine suggests that schizophrenia is associated with an inflammatory syndrome, but the extent to which this syndrome is normalized by antipsychotic treatment has yet to be determined.
Methods:
A systematic quantitative review of the effects of antipsychotics on peripheral cytokine levels in schizophrenia was performed, using follow-up studies providing in vivo cytokine assessments before and after treatment.
Results:
We retrieved 23 studies (total of 762 subjects) which showed that antipsychotic treatment significantly increases plasma levels of soluble interleukin-2 receptor and reduces the plasma levels of interleukin-1β and interferon-γ.
Conclusions:
These results show that antipsychotics produce anti-inflammatory effects in schizophrenia.
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