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Related Experiment Video

Updated: May 6, 2026

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
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Primary hepatic lymphoma: A case report.

Vivian Resende1, Tatiane S Oliveira, Rafael T Gomes

  • 1Department of Surgery, School of Medicine, The Federal University of Minas Gerais, Belo Horizonte, Brazil.

International Journal of Surgery Case Reports
|November 9, 2013
PubMed
Summary

Primary hepatic lymphoma (PHL) is a rare liver cancer that can be misdiagnosed. Early recognition and chemotherapy, such as R-CHOP, are crucial for a good prognosis and potential remission.

Keywords:
DiagnosisLiverPrimary lymphomaTreatment

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Area of Science:

  • Hepatology
  • Oncology
  • Pathology

Background:

  • Primary hepatic lymphoma (PHL) is a rare liver malignancy with frequent misdiagnosis.
  • Differential diagnosis includes fatty infiltration, cirrhosis, amyloidosis, hepatomas, and metastatic neoplasms.
  • Imaging findings can be nonspecific, necessitating biopsy for definitive diagnosis.

Purpose of the Study:

  • To describe a case of primary hepatic lymphoma.
  • To highlight the diagnostic challenges and successful treatment of PHL.
  • To emphasize the importance of early recognition and chemotherapy for PHL.

Main Methods:

  • Case report of a 69-year-old male with weight loss and fatigue.
  • Diagnostic workup included physical examination, MRI, and multiple liver biopsies.
  • Immunohistochemistry confirmed B-lymphocyte lineage.
  • Treatment involved R-CHOP chemotherapy.

Main Results:

  • A large liver tumor was identified via MRI, with normal tumor markers (AFP, CEA).
  • Initial biopsies were inconclusive, but a third biopsy revealed diffuse large B-cell lymphoma.
  • The patient responded well to R-CHOP therapy.

Conclusions:

  • PHL requires prompt recognition due to its favorable response to chemotherapy.
  • Biopsy and immunophenotyping are essential for accurate diagnosis and treatment planning.
  • Early, aggressive chemotherapy can lead to sustained remission in PHL.