Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mitochondrial transplantation reverses the senescence phenotype of SH-SY5Y cells.

Molecular therapy. Advances·2026

Same author

Translating Human Prototype Liver Implant Technology from Academia to Industry for Third-Party Transplant and In Vivo Validation.

Cells·2026

Same author

Fabrication of fusogenic and magnet-responsive cells for transplantation of an intact mitochondrial network.

Acta biochimica et biophysica Sinica·2026

Same author

Fine Regulation of Early Lineage Bifurcations Improves Definitive Endoderm and Hepatocyte Differentiation.

Stem cells and development·2026

Same author

Coronaviruses reprogram the tRNA epitranscriptome to favor viral protein expression.

Nature communications·2026

Same author

Glycosaminoglycans in tissue regeneration: Insights into glycobiology and their biomedical application.

Bioactive materials·2026

Search research articles

Related Experiment Video

Updated: May 6, 2026

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

Published on: October 26, 2011

Modeling human liver biology using stem cell-derived hepatocytes.

Pingnan Sun¹, Xiaoling Zhou, Sarah L Farnworth

¹Shantou University Medical College, Shantou 515041, China. slfarnworth@hotmail.com.

International Journal of Molecular Sciences

|November 9, 2013

Summary

This summary is machine-generated.

Stem cell-derived hepatocytes offer valuable models for studying liver biology and diseases. This review highlights advancements in using these cells for liver disease, drug metabolism, and viral infection research.

More Related Videos

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Published on: January 27, 2023

Defined and Scalable Generation of Hepatocyte-like Cells from Human Pluripotent Stem Cells

Defined and Scalable Generation of Hepatocyte-like Cells from Human Pluripotent Stem Cells

Published on: March 2, 2017

Related Experiment Videos

Last Updated: May 6, 2026

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

Robust Generation of Hepatocyte-like Cells from Human Embryonic Stem Cell Populations

Published on: October 26, 2011

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Human Liver Spheroids from Peripheral Blood for Liver Disease Studies

Published on: January 27, 2023

Defined and Scalable Generation of Hepatocyte-like Cells from Human Pluripotent Stem Cells

Defined and Scalable Generation of Hepatocyte-like Cells from Human Pluripotent Stem Cells

Published on: March 2, 2017

Area of Science:

Hepatology
Stem Cell Biology
Regenerative Medicine

Background:

Human liver disease pathogenesis requires robust in vitro models.
Stem cell technology offers a promising avenue for generating functional liver cells.
Understanding drug metabolism and viral infections in the human liver is crucial.

Purpose of the Study:

To review recent advancements in stem cell-derived hepatocytes.
To highlight the application of these models in studying human liver diseases.
To discuss their utility in drug metabolism and virus infection research.

Main Methods:

Review of current literature on stem cell differentiation protocols for hepatocytes.
Analysis of studies utilizing stem cell-derived hepatocytes for disease modeling.
Examination of research on drug metabolism and viral infections using these cellular models.

Main Results:

Significant progress has been made in generating functional stem cell-derived hepatocytes.
These models show promise in recapitulating aspects of human liver disease.
Applications in drug metabolism and infectious disease research are expanding.

Conclusions:

Stem cell-derived hepatocytes are powerful tools for liver research.
Further development will enhance their utility in personalized medicine and drug discovery.
These models provide critical insights into liver biology and pathology.