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Published on: September 30, 2020
At-risk drinking is independently associated with ICU and one-year mortality in critically ill nontrauma patients*
Arnaud Gacouin1, Jean M Tadie, Fabrice Uhel
11CHU Rennes, Maladies Infectieuses et Réanimation Médicale, Rennes, France. 2Inserm-CIC-0203, Faculté de Médecine, Université Rennes I, IFRI 40, Rennes, France. 3Biosit, Faculté de Médecine, Université Rennes 1, Rennes, France.
Insights
At-risk drinking significantly increases mortality for critically ill nontrauma patients in the ICU and up to a year after discharge. This highlights the importance of addressing alcohol consumption in critical care settings for improved patient survival.
Area of Science:
- Critical Care Medicine
- Alcohol Use Disorders
- Public Health
Background:
- At-risk drinking's impact on nontrauma ICU patient outcomes is not well understood.
- Identifying factors influencing survival in critically ill patients is crucial for improving care.
Purpose of the Study:
- To investigate the independent association between at-risk drinking and mortality in nontrauma ICU patients.
- To assess survival rates in the ICU and within one year post-discharge.
Main Methods:
- An observational cohort study was conducted in a university hospital's mixed ICU.
- 662 adult patients with ICU stays of 3 days or more were included.
- Alcohol consumption was assessed, and patients were categorized as at-risk drinkers based on NIAAA criteria.
Main Results:
- 33% of patients were identified as at-risk drinkers.
- At-risk drinkers showed significantly poorer survival in the ICU (24% vs 13%) and within one year post-discharge.
- Adjusted analyses confirmed at-risk drinking as an independent predictor of both ICU mortality (aOR 1.83) and 1-year post-discharge mortality (aHR 1.70).
Conclusions:
- At-risk drinking is independently associated with increased mortality in critically ill nontrauma patients.
- These findings underscore the need to consider alcohol consumption in the management of ICU patients.
- Early identification and intervention for at-risk drinking may improve long-term survival outcomes.
Objectives:
The impact of at-risk drinking on the outcomes of nontrauma patients is not well characterized. The aim of this study was to determine whether at-risk drinking is independently associated with the survival of nontrauma patients in an ICU and within 1 year following ICU discharge.
Design:
Observational cohort study.
Setting:
A 21-bed mixed ICU in a university hospital.
Patients:
A total of 662 patients who experienced an ICU stay of 3 days or more and for whom alcohol consumption could be assessed.
Interventions:
None.
Measurements And Main Results:
ICU-related variables were collected prospectively, and a 1-year follow-up was determined retrospectively. Analyses were adjusted based on prognostic determinants of short- and long-term outcomes, as previously described in ICU patients and alcohol abusers. Two hundred and eight patients (33%) were identified as at-risk drinkers according to the National Institute on Alcohol Abuse and Alcoholism criteria. Additionally, 111 patients (17%) died in the ICU, and 97 (15%) died after ICU discharge. From the ICU admission until the end of the 1-year follow-up period, the at-risk drinkers exhibited poorer survival than the non-at-risk drinkers (p = 0.0004, as determined by the log-rank test). More specifically, 50 at-risk drinkers (24%) versus 61 non-at-risk drinkers (13%) died in the ICU (p = 0.0009 for the comparison). After adjustment, at-risk drinking remained independently associated with mortality in the ICU (adjusted odds ratio of 1.83; 95% CI of 1.16-2.89; p = 0.01) and with mortality within the year following ICU discharge (adjusted hazard ratio of 1.70; 95% CI of 1.15-2.52; p = 0.008). The causes of death in the at-risk and non-at-risk drinkers were similar.
Conclusions:
In this population of critically ill nontrauma patients, at-risk drinking was independently associated with death in the ICU and within the year following ICU discharge.
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