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Updated: May 6, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
Heteroleptic titanium(IV) catecholato/piperazine systems and their anti-cancer properties
Stuart L Hancock1, Rachel Gati, Mary F Mahon
1Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. mj205@bath.ac.uk.
Abstract:
In this paper we report the synthesis and full characterisation of a range of Ti(IV)-catecholato systems complexed to piperazine or homopiperazine salan ligands. The steric/electronic environment of the catecholate moiety has been varied and the effect this has on cytotoxicity discussed. It was observed that the 7-membered homopiperazine complexes are more stable to hydrolysis than their piperazine cousins in biological media. In general the homopiperazine complexes show higher cytotoxicity than the piperazine complexes, with the most cytotoxic complex exhibiting IC50 (μM) values of 3 ± 0.5 μM (HT-29) and 4 ± 1 μM (OVCAR).
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