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TH17 cell differentiation is regulated by the circadian clock

Xiaofei Yu1, Darcy Rollins, Kelly A Ruhn

  • 1Department of Immunology, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Science (New York, N.Y.)
|November 9, 2013
PubMed
Summary

The circadian clock directly controls the development of T helper 17 (T(H)17) cells, crucial for immunity. This regulation, mediated by NFIL3 and REV-ERBα, impacts inflammatory disease susceptibility.

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