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Updated: May 6, 2026

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
Is glioblastoma an epigenetic malignancy?
Marta Maleszewska1, Bozena Kaminska
1Laboratory of Molecular Neurobiology, Neurobiology Center, The Nencki Institute of Experimental Biology, 3 Pasteur Str., Warsaw 02-093, Poland. B.Kaminska@nencki.gov.pl.
Epigenetic and metabolic enzyme mutations impact glioma development and progression. Reversible epigenetic mechanisms offer novel therapeutic strategies for these incurable brain cancers.
Area of Science:
- Oncology
- Epigenetics
- Metabolic pathways
Background:
- Epigenetic modifications regulate gene expression and are crucial for cell differentiation and cancer development.
- Cancer can alter epigenetic information, and epigenetic dysfunctions can drive oncogenic transformation.
- Interplay between metabolic disturbances, epigenomic changes, and cancer is increasingly recognized, with mutations in metabolic enzymes like SDH, FH, and IDH implicated in cancer.
Purpose of the Study:
- To review current data on mutations in epigenetic and metabolic enzymes in glioma pathobiology.
- To discuss emerging therapies targeting epigenetic modifications for glioma treatment.
Main Methods:
- Literature review of studies on epigenetic and metabolic enzymes in gliomas.
- Analysis of the role of these mutations in glioma development and progression.
- Discussion of therapeutic strategies targeting epigenetic modifications.
Main Results:
- Epigenetic events play a significant role in glioma development and progression.
- Mutations in epigenetic and metabolic enzymes are relevant to glioma pathobiology.
- Emerging therapies targeting epigenetic modifications show promise for glioma treatment.
Conclusions:
- Epigenetic modifications are critical in glioma development and progression.
- Targeting epigenetic mechanisms represents a promising therapeutic avenue for gliomas.
- Combination therapies involving epigenetic modulators may improve treatment outcomes for gliomas.
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