Simple test statistics for major gene detection: a numerical comparison

We compare 22 simple tests for the detection of major gene segregation in livestock populations. These tests belong to two groups: methods based on the comparison of within-family distribution and methods based on the comparison of parents' and offspring performances. The power of the 22 tests and the robustness of the two more powerful of these 22 are evaluated by simulation. Thirteen types of major loci, differing in the within-genotype means, variances or alleles frequencies, are studied. Thirty hierarchically balanced populations defined by the number of sire families (5-20), dams per sire (1-20) and progenies per dam (1-20) are simulated. The quantiles are estimated from 2000 samples, the power from 1000 samples and the robustness from 100 samples. The more powerful tests are the within family-variance heterogenity test (Bartlett test) and the within-family mean-variance regression (Fain 1978). Their robustness may be very low, in particular when the trait distribution is skewed.