Related Experiment Video
Updated: May 6, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
Published on: February 3, 2013
A method to detect large influences of specific sex chromosomes on quantitative traits
1Department of Animal Science, Swiss Federal Institute of Technology, CH-8092, ETH-Zentrum, Zurich, Switzerland.
Abstract:
It is shown that the heterogametic sex of crosses between two highly inbred lines of animals provides a simple means to detect large effects of specific sex chromosomes on quantitative traits. Linear combinations of adjusted trait averages of matching types of crosses between three inbred lines of chickens were used to investigate sex chromosome effects. Evidence for a large influence of the W chromosome of one line on body weight was found. Estimated effects were between 2.4 and 7.2% of the corresponding phenotypic means. The autosomal genetic background exhibited a strong influence on the effect, thus suggesting a sizable amount of epistasis (interaction between sex chromosomes and genetic background).
More Related Videos
08:27Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
10:08Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
Published on: August 12, 2019
Related Concept Videos
The Ratio of X Chromosome to Autosomes
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Dosage Compensation
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will...
X-linked Traits
X-linked Traits
X and Y Chromosomes
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The Y Chromosome Determines Maleness
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....