Herpes simplex virus-enhanced production of autoantibodies against myelin basic protein in mice

In 5 per cent of untreated and apparently healthy Swiss albino mice antibodies were demonstrable against myelin basic protein (MBP) prepared from human brain tissue. Associated with infection with herpes simplex virus (HSV) type 1, enhancement of the antibody formation against MBP was encountered. Thus of infected but symptom-free animals 15-25 per cent revealed anti-MBP antibodies. The latter type of antibodies appeared later than antibodies against HSV and were found predominantly in animals inoculated via the intraperitoneal route. No signs of demyelination in spinal cords or spinal nerve roots were observed in MBP antibody-positive HSV-immunized animals. Results reported may indicate triggering of an autoantibody formation against MBP and are discussed in relation to demyelinating disease.