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Preimplantation stress and development.

Sky Feuer¹, Paolo Rinaudo

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Reproductive Endocrinology and Infertility, University of California, San Francisco, California, 94115.

Birth Defects Research. Part C, Embryo Today : Reviews

|November 9, 2013

Summary

This summary is machine-generated.

Early life stress can impact adult health, particularly for children conceived via assisted reproductive technologies (ART). Long-term health outcomes for ART-conceived individuals require further investigation.

Keywords:

assisted developmental‐origin‐of‐health‐and‐disease hypothesis in vitro culture preimplantation stress reproductive technologies

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Area of Science:

Developmental biology
Reproductive medicine
Public health

Background:

The developmental origins of health and disease (DOHaD) hypothesis links early-life environmental exposures to adult disease risk.
Assisted reproductive technologies (ART) are increasingly used, with millions of children conceived via these methods.
Postnatal effects in ART-conceived children are often overlooked, despite the focus on live birth.

Purpose of the Study:

To review the impact of early developmental stress on future health.
To assess the long-term health outcomes of individuals conceived through ART.

Main Methods:

Literature review analyzing studies on early-life stress and health.
Examination of evidence regarding adverse consequences in ART-conceived children.

Main Results:

Evidence on adverse outcomes in ART-conceived children is controversial.
Most studies show no significant problems, but isolated cases of diseases and malformations are reported.
Animal studies indicate metabolic pathway alterations following preimplantation stress.

Conclusions:

Long-term follow-up of ART-conceived individuals is crucial.
Understanding the impact of early environmental cues on adult health is important for ART outcomes.