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Obstructive sleep apnea and endothelial progenitor cells.

Qing Wang1, Qi Wu, Jing Feng

  • 1The Second Respiratory Department of the First People's Hospital of Kunming, Yunnan, People's Republic of China.

Patient Preference and Adherence
|November 9, 2013
PubMed
Summary

Obstructive sleep apnea (OSA) is linked to reduced endothelial progenitor cells (EPCs), crucial for vascular repair. Continuous positive airway pressure (CPAP) therapy can improve EPC function in OSA patients.

Keywords:
continuous positive airway pressure adherenceintermittent hypoxiaoxidative stresssympathetic activationsystemic inflammation

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Area of Science:

  • Cardiovascular Medicine
  • Sleep Medicine
  • Cell Biology

Background:

  • Obstructive sleep apnea (OSA) is prevalent and a risk factor for cardiovascular diseases.
  • Endothelial injury is central to OSA's cardiovascular pathology.
  • Endothelial progenitor cells (EPCs) are vital for vascular repair and integrity.

Purpose of the Study:

  • To explore the relationship between EPC numbers/function and OSA.
  • To elucidate molecular mechanisms linking OSA to EPC dysfunction.

Main Methods:

  • Literature review of OSA pathogenesis.
  • Analysis of studies on EPCs in OSA patients.
  • Investigation of molecular pathways affecting EPCs in OSA.

Main Results:

  • Most studies show reduced circulating EPCs in OSA patients.
  • Mechanisms include inflammation, oxidative stress, sympathetic activation, and impaired EPC mobilization/function.
  • Continuous positive airway pressure (CPAP) therapy positively impacts EPCs.

Conclusions:

  • OSA negatively affects EPC number and function through various pathophysiological pathways.
  • CPAP therapy can restore EPC function by mitigating OSA's effects.
  • Improving CPAP adherence through patient support and comfortable titration is crucial.