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Updated: Jan 26, 2026

Purification, Expansion, and Flow Cytometry-Based Phenotyping of Mouse Derived Bone Marrow Mesenchymal Stem Cells
Published on: July 11, 2025
Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma
Ying Hu1, Hai Bo Tan, Xin Mei Wang
1Departments of Ophthalmology, Shanghai East Hospital of Tongji University, Shanghai, People's Republic of China ; Departments of Ophthalmology, First Affiliated Hospital, Harbin, People's Republic of China.
Abstract:
Glaucoma is a common eye disease in the aged population and has severe consequences. The present study examined the therapeutic effects of bone marrow mesenchymal stem cell (BMSC) transplantation in preventing loss of visual function in aged rats with glaucoma caused by laser-induced ocular hypertension. We found that BMSCs promoted survival of retinal ganglion cells in the transplanted eye as compared with the control eye. Further, in swimming tests guided by visual cues, the rats with a BMSC transplant performed significantly better. We believe that BMSC transplantation therapy is effective in treating aged rats with glaucoma.
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