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Measles contributes to rheumatoid arthritis: evidence from pathway and network analyses of genome-wide association

Guiyou Liu1, Yongshuai Jiang, Xiaoguang Chen

  • 1Institute of Neurology, Guangdong Medical College, Zhanjiang, China ; Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.

Plos One
|November 9, 2013
PubMed

Insights

This study suggests shared genetic pathways link rheumatoid arthritis (RA) and measles. Pathway analysis identified key immune signaling routes, potentially explaining the observed association between these conditions.

Area of Science:

  • Immunology
  • Genetics
  • Rheumatology

Background:

  • Epidemiological studies suggest an association between rheumatoid arthritis (RA) and measles.
  • The underlying mechanism for this link remains unclear.
  • Shared genetic pathways are hypothesized to contribute to the RA-measles association.

Purpose of the Study:

  • To investigate shared genetic pathways between rheumatoid arthritis (RA) and measles.
  • To identify specific biological pathways implicated in the association between RA and measles using genome-wide association studies (GWAS).

Main Methods:

  • Pathway analysis was performed on a large-scale rheumatoid arthritis (RA) genome-wide association studies (GWAS) dataset.
  • Findings were validated using established RA loci, protein-protein interaction networks, and prior GWAS pathway analyses of autoimmune diseases.

Main Results:

  • Four known RA-associated pathways were confirmed: Cytokine-cytokine receptor interaction, Jak-STAT signaling, T cell receptor signaling, and Cell adhesion molecules.
  • The study highlights, for the first time, the involvement of Measles and Intestinal immune network for IgA production pathways in RA pathogenesis.
  • These findings suggest shared genetic underpinnings between RA and measles.

Conclusions:

  • Shared genetic pathways, including those related to measles and IgA production, may explain the association between rheumatoid arthritis (RA) and measles.
  • The results offer insights into RA pathogenesis and may aid in developing novel therapeutic strategies.

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