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Related Experiment Video

Updated: May 6, 2026

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

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Steroid-associated hip joint collapse in bipedal emus.

Li-Zhen Zheng¹, Zhong Liu, Ming Lei

¹Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China.

|November 9, 2013

Summary

This study developed a bipedal emu model for steroid-associated osteonecrosis (SAON) to test treatments for hip joint collapse. The model effectively mimics human SAON, aiding preclinical research for prevention strategies.

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Area of Science:

Orthopedics
Preclinical Research
Animal Models

Background:

Steroid-associated osteonecrosis (SAON) is a debilitating condition.
Current preclinical models for SAON have limitations.
Effective models are needed for developing preventative treatments.

Purpose of the Study:

To establish a bipedal emu model for SAON.
To evaluate the efficacy of a combined pulsed lipopolysaccharide (LPS) and methylprednisolone (MPS) protocol for SAON induction.
To assess the model's suitability for testing therapeutic interventions.

Main Methods:

Five adult male emus received pulsed LPS and MPS; three served as controls.
Gait analysis, MRI, and blood tests were performed post-induction.
Micro-CT, histomorphometry, and SEM were used for bone and tissue analysis.

Main Results:

Steroid-treated emus exhibited limping gait and abnormal MRI signals.
SAON developed in all treated emus, with a 70% incidence of joint collapse.
Significant changes in neutrophil percentage, lipid metabolism, subchondral bone structure, and cartilage were observed.

Conclusions:

The pulsed LPS and MPS protocol effectively induces SAON and hip joint collapse in emus.
Bipedal emus serve as a viable preclinical model for SAON research.
This model can be used to evaluate potential treatments for preventing steroid-induced hip joint collapse.