Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The fibrinolytic system in man.

D Collen, H R Lijnen

    Critical Reviews in Oncology/Hematology
    |January 1, 1986
    PubMed
    Summary

    The fibrinolytic system regulates blood clot breakdown. Imbalances in this system can lead to thrombosis or bleeding, but recombinant tissue-type plasminogen activator shows promise for clot-selective therapy.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Impaired fibrinolysis and the risk for coronary heart disease.

    Circulation·1996
    Same author

    Characterization of the murine plasminogen/urokinase-type plasminogen-activator system.

    European journal of biochemistry·1996
    Same author

    Correlation between oxidized low density lipoproteins and von Willebrand factor in chronic renal failure.

    Thrombosis and haemostasis·1996
    Same author

    Inhibition of tissue angiotensin-converting enzyme with quinapril reduces hypoxic pulmonary hypertension and pulmonary vascular remodeling.

    Circulation·1996
    Same author

    A pilot study on bolus administration of recombinant staphylokinase for coronary artery thrombolysis.

    Thrombosis and haemostasis·1996
    Same author

    Role of tissue factor in embryonic blood vessel development.

    Nature·1996

    Area of Science:

    • Biochemistry
    • Hematology
    • Molecular Biology

    Background:

    • The fibrinolytic system is crucial for dissolving blood clots.
    • It involves plasminogen activation to plasmin, which degrades fibrin.
    • Regulation occurs through interactions between plasminogen, activators, and inhibitors.

    Purpose of the Study:

    • To elucidate the regulatory mechanisms of the fibrinolytic system.
    • To understand the molecular interactions governing fibrinolysis in human blood.
    • To explore the potential of recombinant tissue-type plasminogen activator (rt-PA) in thrombolytic therapy.

    Main Methods:

    • Review of the molecular components and interactions within the fibrinolytic system.
    • Analysis of plasminogen activation and inhibition pathways.
    • Examination of evidence from animal models regarding rt-PA efficacy.

    Main Results:

    • Fibrinolysis is triggered and localized to fibrin, with localized plasmin generation.
    • Systemic plasminogen activation is normally absent in plasma.
    • Imbalances in fibrinolysis can cause thrombosis or bleeding; rt-PA demonstrates clot-selective properties.

    Conclusions:

    • The fibrinolytic system's regulation is complex, involving localized activation and inhibition.
    • Dysregulation contributes to thrombotic and hemorrhagic disorders.
    • Recombinant tissue-type plasminogen activator offers a promising, targeted approach for thrombolysis with potentially fewer side effects.

    Related Experiment Videos