Binaural interaction in the auditory middle latency response of the guinea pig

Binaural interaction in the guinea pig middle latency response (MLR) was studied using two stimulus paradigms: binaural click stimuli and monaural click stimuli with contralateral white noise. During monaural click stimulation, the MLR is largest in amplitude over the contralateral temporal lobe. Binaural click stimulation reduces the amplitude of this response. Monaurally evoked click responses are also altered by the presentation of continuous white noise in the contralateral ear. The addition of white noise results in an increase in amplitude particularly of components A (12 msec) and B (17 msec). These alterations in response amplitude are specific to the MLR with no change occurring in the auditory brain-stem response (ABR). These findings appear to reflect interaction between the generators of middle latency response.