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Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

26
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
26
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.5K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.5K
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

49
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
49
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

27
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
27
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

918
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
918
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.2K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.2K

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Related Experiment Video

Updated: May 6, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
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[Hypertriglyceridemia-induced pancreatitis].

Daiji Nagayama1, Kohji Shirai

  • 1Center of Diabetes, Endocrinology and Metabolism.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|November 12, 2013
PubMed
Summary

Hypertriglyceridemia-induced pancreatitis (HTGP) is severe. Genetic variants in apolipoprotein AV (ApoAV) may contribute to HTGP, alongside lipoprotein lipase (LPL) gene variants.

Area of Science:

  • Biochemistry
  • Genetics
  • Gastroenterology

Context:

  • Acute pancreatitis affects 27.7 per 100,000 in Japan.
  • Hypertriglyceridemia-induced pancreatitis (HTGP) accounts for 1.4% of cases.
  • HTGP presents with higher severity and complication rates.

Purpose:

  • To investigate the genetic factors contributing to severe hypertriglyceridemia in patients with HTGP.
  • To explore the role of apolipoprotein AV (ApoAV) variants in HTGP pathogenesis.
  • To identify potential genetic markers for HTGP beyond lipoprotein lipase (LPL) abnormalities.

Summary:

  • A study of 21 HTGP patients found ApoAV Gly185-Cys polymorphism in 42.9% and LPL gene variants in 14.3%.
  • No patients exhibited ApoCII deficiency.

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  • These findings suggest ApoAV variants are frequently involved in HTGP, in addition to LPL gene variants.

    • Impact:

    • Highlights the importance of investigating hypertriglyceridemia pathogenesis in pancreatitis.
    • Suggests routine genetic screening for ApoAV and LPL variants in HTGP patients.
    • Informs clinical management strategies for HTGP based on specific underlying genetic factors.