[Features of hypertriglyceridemia in chronic kidney disease(CKD)]

In advanced chronic kidney disease(CKD), chylomicrons(CM) and very low density lipoprotein(VLDL) are accumulated by the inactivity of lipoprotein lipase(LPL). CM remnants are incompletely absorbed into liver and the conversion of intermediate lipoprotein (IDL) to cholesterol-rich low density lipoprotein(LDL) is impaired by the lack of hepatic triglyceride lipase(HTGL). As a result, the increase of triglyceride-rich lipoproteins, i.e., CM, CM remnants, VLDL and IDL, shows hypertriglyceridemia. The ratio of triglyceride to cholesterol is also increased in both LDL and HDL. Excess triglyceride-rich lipoproteins are oxidized by oxidative stress in CKD and involved in cardio-vascular diseases. Accordingly, the prevention of hypertriglyceridemia is one of the most important steps for the treatment of CKD.