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Related Concept Videos

Drug Therapy01:28

Drug Therapy

450
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
450
Drug Administration and Therapy Phases: Overview01:26

Drug Administration and Therapy Phases: Overview

2.0K
Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...
2.0K
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

4.1K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
4.1K
Drug toxicity: Drug–Drug Interaction01:30

Drug toxicity: Drug–Drug Interaction

437
Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
437
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

605
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
605
Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

3.7K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
3.7K

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Related Experiment Video

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Diagonal Method to Measure Synergy Among Any Number of Drugs
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[Introduction to drug therapy].

Hideto Ishii1, Masayuki Yoshida

  • 1Life Science and Bioethics, Tokyo Medical and Dental University.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|November 12, 2013
PubMed
Summary

Lifestyle changes are primary for high triglycerides (TG), but medication is often necessary. This paper guides when to initiate treatment and select drugs, referencing Japan Atherosclerosis Society guidelines and WHO dyslipidemia classifications.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Pharmacology

Context:

  • High triglycerides (TG) are a significant risk factor for atherosclerosis and cardiovascular disease.
  • Diet and exercise are foundational but frequently insufficient for managing hypertriglyceridemia.
  • Current treatment guidelines necessitate a structured approach to initiating and managing TG-lowering therapies.

Purpose:

  • To delineate the criteria for initiating pharmacological treatment in patients with high triglycerides.
  • To provide guidance on selecting appropriate medications based on dyslipidemia classification.
  • To review the role of fibrates and novel agents like EPA/DHA in managing high TG.

Summary:

  • Treatment for high triglycerides (TG) typically begins with diet and exercise, but medication is often required.

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  • Guidelines from the Japan Atherosclerosis Society inform treatment initiation and drug selection, referencing WHO dyslipidemia classifications.
  • Fibrates are key therapeutic agents, with novel EPA/DHA formulations showing promise for high TG and atherosclerosis.

    • Impact:

    • This guidance aids clinicians in optimizing treatment strategies for hypertriglyceridemia.
    • Improved management of high TG can reduce the risk of atherosclerosis and related cardiovascular events.
    • Highlights the potential of new therapeutic agents in addressing TG-related metabolic dysfunction.