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Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

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Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers01:20

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Class IV antiarrhythmic drugs, such as verapamil and diltiazem, block calcium channels. They primarily affect the heart, slowing the conduction in calcium-dependent tissues like the SA and AV nodes. These drugs manage reentrant supraventricular tachycardia (SVT) and reduce ventricular rate in atrial flutter/fibrillation.
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Calcium channel blockers, a class of antiepileptic drugs, regulate the flow of calcium ions within neurons.
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Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
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Related Experiment Video

Updated: May 6, 2026

Advancements in the Metabolic Profiling of Three-Dimensional Brain Tumor Spheroids for Drug Screening
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[Fibrates].

Fumihiko Hara1, Junichi Yamazaki

  • 1Division of Cardiovasucular Medicine, Department of Internal Medicine, Toho University Omori Medical Center.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|November 12, 2013
PubMed
Summary

Fibrates, though historically used, show promise beyond statins. Recent large-scale trials reveal benefits in cardiovascular events, atherosclerosis prevention, and diabetic complications, warranting further clinical evidence.

Area of Science:

  • Pharmacology
  • Cardiovascular Medicine
  • Endocrinology

Context:

  • Fibrates are a class of lipid-lowering drugs with a long history of use.
  • Despite their history, clinical adoption and profitability lag behind statins.
  • Recent large-scale clinical trials have highlighted novel therapeutic benefits of fibrates.

Purpose:

  • To review the emerging clinical evidence for fibrate therapy.
  • To highlight the multifaceted benefits of fibrates beyond lipid-lowering.
  • To underscore the need for further clinical investigation and evidence accumulation.

Summary:

  • Large-scale clinical studies indicate that fibrates can reduce cardiovascular events.
  • Fibrates demonstrate efficacy in controlling atherosclerosis progression.

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  • Evidence suggests a positive impact of fibrates on diabetic microangiopathy.

    • Impact:

    • The findings suggest fibrates may offer a valuable therapeutic option in cardiovascular disease and diabetes management.
    • Further clinical evidence is expected to solidify the role of fibrates in modern pharmacotherapy.
    • This could lead to increased clinical utilization and improved patient outcomes.