Octaoctyl-substituted lutetium bisphthalocyanine for NADH biosensing

Area of Science:

• Electrochemistry
• Spectroscopy
• Materials Science

Background:

• Phthalocyanines are versatile macrocyclic compounds with applications in electronics and sensing.
• Lutetium bis-phthalocyanine (R16LuPc2) offers unique redox properties due to its sandwich structure.

Purpose of the Study:

• To investigate the electrochemical and spectroscopic properties of R16LuPc2 thin films.
• To evaluate the potential of R16LuPc2 as a sensor for dihydronicotinamide adenine dinucleotide (NADH).

Main Methods:

• Cyclic voltammetry was used to study redox processes.
• UV-visible absorption and Raman spectroscopy were employed to analyze spectral changes.
• Electrochemical measurements were performed in aqueous LiClO4 solutions.

Main Results:

• R16LuPc2 films showed one-electron quasi-reversible redox processes.
• Oxidation led to a red-shift in the Q-band, indicating shorter inter-ring distances.
• Reduction by NADH was observed, with slower kinetics for aged films.

Conclusions:

• Spectral shifts correlate with charge localization on phthalocyanine rings.
• R16LuPc2 film performance is influenced by age and NADH concentration.
• The study supports the use of R16LuPc2 as a potential NADH sensor.