Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of intraoperative specimen computed tomography imaging on grossing accuracy and margin assessment in pulmonary wedge resection.

JTCVS open·2026
Same author

Metabolomic atlas of ischemia-reperfusion injury in human lung transplants: Mitochondrial stress and primary graft dysfunction.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2026
Same author

The need for clarity among the shadows: It is time to further refine the definition of primary graft dysfunction in lung transplant recipients.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same author

The American Association for Thoracic Surgery (AATS) 2026 Expert Consensus Document: Guidelines for donor/recipient size-matching in lung transplantation.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Preoperative circulating tumor DNA detection and occult lymph node metastases in clinical stage I lung cancer: The lung DETECT study.

JTCVS open·2026
Same author

Ten-year review of endobronchial ultrasound-guided transbronchial needle aspiration for lymph node staging in lung cancer: Comparison with guidelines.

JTCVS open·2026
Same journal

Social Determinants of Health, Health Disparities, and Surgical Equity.

The Surgical clinics of North America·2026
Same journal

Beyond the Scalpel's Reach.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Society.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Hospitals.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions for Providers.

The Surgical clinics of North America·2026
Same journal

Stepwise Solutions-Patients Social Determinants of Health, Health Disparities, and Surgical Equity.

The Surgical clinics of North America·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program
08:59

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Published on: February 25, 2015

30.2K

Advances in lung preservation.

Tiago N Machuca1, Marcelo Cypel, Shaf Keshavjee

  • 1Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, 9N969, Toronto, Ontario M5G 2C4, Canada.

The Surgical Clinics of North America
|November 12, 2013
PubMed
Summary
This summary is machine-generated.

Ex vivo lung perfusion (EVLP) offers a functional, normothermic approach to lung preservation, moving beyond static cold ischemia. This method supports the lung's metabolism and repair, enhancing organ viability for transplantation.

Keywords:
Ex vivo lung perfusionLung transplantationNon–heart beating donorOrgan preservationOrgan procurement

More Related Videos

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
09:54

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

2.3K
Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death
09:14

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death

Published on: October 18, 2024

1.3K

Related Experiment Videos

Last Updated: May 6, 2026

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program
08:59

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Published on: February 25, 2015

30.2K
Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
09:54

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

2.3K
Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death
09:14

Establishment of a Novel Ex Vivo Lung Perfusion System for Rat Lungs After Circulatory Death

Published on: October 18, 2024

1.3K

Area of Science:

  • Thoracic surgery
  • Organ transplantation
  • Cardiopulmonary medicine

Background:

  • Conventional lung preservation relies on static cold ischemia, which has limitations.
  • Ex vivo lung perfusion (EVLP) represents a paradigm shift in organ preservation.
  • EVLP utilizes functional normothermia to maintain lung viability.

Purpose of the Study:

  • To review the rationale and benefits of ex vivo lung perfusion.
  • To discuss the technical aspects and clinical experience of EVLP.
  • To explore personalized medicine approaches for donor lung injury using EVLP.

Main Methods:

  • Review of conventional lung preservation techniques.
  • Discussion of the principles and application of ex vivo lung perfusion.
  • Analysis of clinical data and outcomes associated with EVLP.

Main Results:

  • EVLP enables functional normothermia, supporting lung metabolism.
  • This approach facilitates the restoration of reparative processes in donor lungs.
  • EVLP allows for targeted assessment and potential treatment of specific donor organ injuries.

Conclusions:

  • Ex vivo lung perfusion has transformed lung preservation from static to dynamic.
  • Normothermic perfusion supports intrinsic lung repair mechanisms.
  • EVLP opens avenues for personalized medicine in lung transplantation.