Elevation of serum gamma-glutamyl transpeptidase in end-stage chronic renal failure

The serum gamma-glutamyl transpeptidase (GGT) was measured on 32 randomly selected patients about to commence or already on chronic haemodialysis. Raised values were found in 12 patients (37%). None of these patients had received drugs known to affect hepatic microsomes and all had normal liver function tests. The possible significance of this surprising finding is discussed.