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Imaging of iron

Petr Dusek1, Monika Dezortova, Jens Wuerfel

  • 1Department of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic; Institut für interventionelle und diagnostische Neuroradiologie, Universitätsmedizin Göttingen, Göttingen, Germany.

International Review of Neurobiology
|November 12, 2013
PubMed

Insights

Magnetic resonance imaging (MRI) offers noninvasive in vivo iron quantification. Advanced MRI techniques improve iron measurement specificity for diagnosing neurological disorders and monitoring disease.

Area of Science:

  • Biomedical Imaging
  • Neuroimaging
  • Medical Physics

Background:

  • Magnetic resonance imaging (MRI) allows noninvasive in vivo iron quantification in organs.
  • Iron storage compounds like ferritin and hemosiderin alter MRI signals due to their magnetic properties.
  • Standard T2-weighted MRI signal changes in iron-rich areas are influenced by factors beyond iron concentration.

Purpose of the Study:

  • To review and categorize advanced in vivo MRI techniques for specific iron quantification.
  • To highlight the importance of accurate cerebral iron concentration estimates in neurological conditions.
  • To discuss the potential of iron monitoring as a biomarker for diagnosis and treatment.

Main Methods:

  • Relaxometry techniques measure relaxation times influenced by magnetic susceptibility.
  • Magnetic field correlation imaging analyzes field variations caused by magnetic materials.
  • Phase-based contrast methods, including susceptibility-weighted imaging and quantitative susceptibility mapping, detect magnetic susceptibility differences.

Main Results:

  • Advanced MRI techniques offer improved specificity for iron quantification compared to conventional methods.
  • Characteristic iron deposition patterns visualized by MRI aid in diagnosing neurological disorders.
  • Accurate iron concentration measurements are crucial for understanding aging and diseases like neurodegeneration.

Conclusions:

  • Novel MRI methods provide more specific in vivo iron quantification.
  • Accurate iron assessment is vital for diagnosing and managing neurological diseases.
  • Monitoring iron levels may serve as a sensitive biomarker for disease progression and therapeutic response.
Keywords:
Chelating agentsIronMRINBIANeurodegenerationRelaxometrySWI

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