Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

Cardiac Output II: Effect of Stroke Volume on Cardiac Output

4.7K
Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
Preload refers to the initial elongation of the cardiac myocytes before contraction and is related to the volume of blood filling the heart at the end of diastole, or end-diastolic volume. The...
4.7K
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

7.4K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
7.4K
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

53
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
53
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

68
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
68

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Utilization of Tumor Markers for Intraoperative Specimen Radiography Does Not Decrease the Rate of Margin Positivity in Breast Conservation Surgery (BCS).

The American surgeon·2026
Same author

The influence of visual input and attention on gait initiation in people with Parkinson disease.

PloS one·2026
Same author

Identifying Disparities in Timely Receipt of Radiation After Breast-Conserving Surgery.

The breast journal·2026
Same author

Characterization of Lower Extremity Pain in Ambulatory Individuals After Stroke.

Archives of physical medicine and rehabilitation·2026
Same author

Empowering stroke survivors beyond inpatient rehabilitation: the STRIDE program.

Frontiers in stroke·2026
Same author

Outdoor ground surface influences spatiotemporal parameters of walking for individuals undergoing rehabilitation: An observational study.

PloS one·2025
Same journal

Corrigendum to "Kinematic effects of two therapeutic interventions for glenohumeral joint instability: A preliminary feasibility trial" [J. Electromyogr. Kinesiol. 88 (2026) 103147].

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026
Same journal

Investigating the effects of conservative treatments on the flexion relaxation phenomenon for chronic low back pain: A systematic review.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026
Same journal

Activation of the deep lumbar multifidus during common rehabilitation and resistance exercises.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026
Same journal

Comprehensive RGBD-based shoulder kinematics using markerless anatomical landmarks detection and a 3D-printed acromial cluster during hand-cycling.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026
Same journal

Variational mode decomposition based on refined composite multiscale dispersion entropy and its application in sEMG Denoising.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026
Same journal

Does pain alter the spatial distribution of muscle activity in people experiencing spinal pain? A systematic review and meta-analysis.

Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
08:01

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

10.9K

Loading and knee flexion after stroke: Less does not equal more.

Mary Murray1, Amy Hardee2, Richard L Goldberg3

  • 1Division of Physical Therapy, Department of Allied Health Sciences, University of North Carolina at Chapel Hill, USA; Cleveland Clinic, Cleveland, OH, USA.

Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology
|November 12, 2013
PubMed
Summary
This summary is machine-generated.

Limb loading, like ankle weights or body weight support, minimally affects knee extensor activity in individuals post-stroke. This suggests limb loading adjustments may not effectively treat stiff-knee gait after stroke.

Keywords:
Force feedbackGaitRehabilitationStiff-knee gaitStroke

More Related Videos

The Impact of Motor Task Conditions on Goal-Directed Arm Reaching Kinematics and Trunk Compensation in Chronic Stroke Survivors
15:00

The Impact of Motor Task Conditions on Goal-Directed Arm Reaching Kinematics and Trunk Compensation in Chronic Stroke Survivors

Published on: May 2, 2021

3.0K
Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
14:55

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

16.5K

Related Experiment Videos

Last Updated: May 6, 2026

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke
08:01

Compensatory Limb Use and Behavioral Assessment of Motor Skill Learning Following Sensorimotor Cortex Injury in a Mouse Model of Ischemic Stroke

Published on: July 10, 2014

10.9K
The Impact of Motor Task Conditions on Goal-Directed Arm Reaching Kinematics and Trunk Compensation in Chronic Stroke Survivors
15:00

The Impact of Motor Task Conditions on Goal-Directed Arm Reaching Kinematics and Trunk Compensation in Chronic Stroke Survivors

Published on: May 2, 2021

3.0K
Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
14:55

Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

16.5K

Area of Science:

  • Neuroscience
  • Biomechanics
  • Rehabilitation Science

Background:

  • Force feedback is thought to influence lower extremity extensor activity during gait.
  • Understanding factors modulating muscle activity is crucial for stroke rehabilitation.

Purpose of the Study:

  • To investigate the effect of limb loading on knee extensor excitability during the late stance/early swing phase of gait in individuals with post-stroke hemiparesis.
  • To determine if ankle loading or body weight support impacts quadriceps muscle activity and knee kinematics.

Main Methods:

  • Ten individuals with chronic hemiparesis underwent seated quadriceps reflex testing with varying ankle loads (0-0.4Nm/kg).
  • Gait analysis was performed on a treadmill with 0%, 20%, or 40% body weight support (BWS).
  • Reflex responses were recorded from vastus lateralis (VL), rectus femoris (RF), and vastus medialis (VM); knee kinematics and muscle activity were measured during gait.

Main Results:

  • Ankle loading at 0.2Nm/kg slightly reduced the prolonged response in the vastus medialis (p=0.04) but did not significantly alter other quadriceps excitability measures (p>0.08).
  • Body weight support during gait did not influence knee kinematics (p=0.18) or quadriceps muscle activity (p>0.17) during the late stance/early swing phase.

Conclusions:

  • Load sensed at the ankle appears to have a minimal effect on the ipsilateral quadriceps during late stance in individuals post-stroke.
  • Adjusting limb loading during rehabilitation may not be an effective strategy for addressing stiff-knee gait following stroke.