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C-reactive protein and long-term ischemic stroke prognosis
Reyna L VanGilder1, Danielle M Davidov2, Kyle R Stinehart3
1Morgantown Department, West Virginia University School of Nursing, Morgantown, WV, USA; Department of Emergency Medicine, West Virginia University School of Medicine, P.O. Box 9303, Morgantown, WV 26506, USA.
Summary
Elevated C-reactive protein (CRP) levels shortly after ischemic stroke predict poor long-term functional recovery. This finding highlights CRP
Area of Science:
- Neurology
- Biomarkers
- Inflammation
Background:
- C-reactive protein (CRP) is an inflammatory biomarker linked to vascular disease progression.
- Existing research on CRP's prognostic value for ischemic stroke outcomes is conflicting, often focusing on mortality.
- Functional impairment is a significant post-stroke issue, suggesting a need for biomarkers predicting recovery.
Purpose of the Study:
- To systematically review the literature on the relationship between C-reactive protein (CRP) and long-term functional outcomes in ischemic stroke patients.
- To evaluate the current evidence regarding CRP as a predictor of functional recovery after stroke.
- To identify research gaps concerning inflammatory markers and stroke prognosis.
Main Methods:
- Systematic literature search of PubMed and MEDLINE databases (1989-2012).
- Inclusion criteria: original studies, acute CRP levels within 24 hours of symptom onset, neuroimaging confirmation of ischemic stroke, high-sensitivity CRP assay, and functional outcome assessment beyond 30 days.
- Study quality assessed using REMARK recommendations.
Main Results:
- Five studies met all inclusion criteria.
- A significant association was found between elevated baseline high-sensitivity CRP levels and unfavorable long-term functional outcomes.
- The reviewed studies consistently indicated a link between higher CRP and poorer stroke recovery.
Conclusions:
- Elevated acute high-sensitivity CRP is associated with unfavorable long-term functional outcomes in ischemic stroke patients.
- Further research is needed to clarify the relationship between inflammatory markers and functional recovery.
- Prospective studies are warranted to confirm the predictive value of high-sensitivity CRP for long-term stroke outcomes.
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