Related Experiment Video

Updated: May 6, 2026

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
11:32

Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

Published on: February 23, 2014

14.7K

Mortality indicators in pneumococcal meningitis: therapeutic implications

Hakan Erdem1, Nazif Elaldi2, Nefise Öztoprak3

  • 1GATA Haydarpasa Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|November 12, 2013
PubMed
Abstract

Insights

Critical illness and older age predict mortality in pneumococcal meningitis. Penicillin-susceptible bacteria were linked to better outcomes, while vancomycin showed no significant survival benefit.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Epidemiology

Background:

  • Pneumococcal meningitis remains a significant cause of mortality globally.
  • Understanding mortality indicators is crucial for improving patient outcomes.
  • Therapeutic strategies require continuous evaluation against evolving antimicrobial resistance patterns.

Purpose of the Study:

  • To identify key indicators of mortality in pneumococcal meningitis.
  • To evaluate the therapeutic implications of different treatment regimens.
  • To assess the impact of antimicrobial resistance on treatment efficacy.

Main Methods:

  • A 15-year retrospective, multicenter cohort study (1998-2012).
  • Inclusion of 306 culture-positive pneumococcal meningitis cases from 38 centers.
  • Analysis of patient data, isolate susceptibility, and treatment outcomes.

Main Results:

  • Critical illness (OR 7.09) and age >50 years (OR 3.91) were independent mortality predictors.
  • Infection with penicillin-susceptible isolates showed a protective effect (OR 0.44).
  • Empirical vancomycin use did not demonstrate a statistically significant survival benefit (OR 2.16).

Conclusions:

  • Ceftriaxone monotherapy is insufficient for pneumococcal meningitis caused by penicillin-resistant strains.
  • Vancomycin trended towards improved prognosis but lacked statistical significance.
  • Further research is necessary to optimize treatment protocols for pneumococcal meningitis, especially with resistant pathogens.
Keywords:
MeningitisMortalityPenicillinResistanceStreptococcus pneumoniaeVancomycin

More Related Videos

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

7.0K

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
31
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
1.4K
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
1.2K
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
4.2K
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
45
Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
88