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Diabetic Retinopathy

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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Detecting Abnormalities in Choroidal Vasculature in a Mouse Model of Age-related Macular Degeneration by Time-course Indocyanine Green Angiography

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Published on: February 19, 2014

Association between hyperacuity defects and retinal microstructure in polypoidal choroidal vasculopathy.

Moosang Kim, Seung-Young Yu¹, Hyung-Woo Kwak

¹Department of Ophthalmology, College of Medicine, Kyung Hee University, Seoul, Korea.

Indian Journal of Ophthalmology

|November 12, 2013

Summary

Hyperacuity defects in polypoidal choroidal vasculopathy (PCV) are linked to photoreceptor damage. Inner retinal lesions invading the photoreceptor layer worsen these visual acuity defects.

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Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Application of Optical Coherence Tomography to a Mouse Model of Retinopathy

Published on: January 12, 2022

Area of Science:

Ophthalmology
Retinal Diseases
Visual Function

Background:

Polypoidal choroidal vasculopathy (PCV) is a common cause of vision loss.
Hyperacuity defects can impact visual function in PCV patients.

Purpose of the Study:

To correlate preferential hyperacuity perimetry (PHP) findings with spectral-domain optical coherence tomography (OCT) identified retinal microstructural changes in PCV.
To enhance understanding of hyperacuity defects in PCV.

Main Methods:

Retrospective review of 28 eyes from 28 PCV patients.
Ophthalmologic examination including best-corrected visual acuity, PHP, and OCT.
Analysis of PHP test score and total volume of hyperacuity defect zone.

Main Results:

Eyes with hyperacuity defects showed significantly more photoreceptor layer disruption (P=0.0001).
Mean visual acuity was worse in the hyperacuity defect group (0.82) vs. intact group (0.46) (P=0.014).
Intra-retinal pathology within the hyperacuity defect zone correlated with higher PHP scores and larger defect volumes.

Conclusions:

Hyperacuity defects in PCV are associated with photoreceptor disarrangement.
PCV lesions affecting the inner retina and photoreceptor layer correlate with more severe hyperacuity defects.