Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is the Immune System?01:38

What is the Immune System?

100.3K
Overview
100.3K
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

121
Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular...
121
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

65.0K
Overview
65.0K
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

36
PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
36
Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

57
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
57
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.5K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatokines lipocalin 2 and osteopontin drive muscle atrophy in MASH.

Molecular metabolism·2026
Same author

A deep-learning framework reveals whole-body perturbations at cell level.

Nature·2026
Same author

Inhibition of ceramide synthesis ameliorates body wasting in a cancer cachexia model.

The Journal of clinical investigation·2026
Same author

TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network.

Nature communications·2026
Same author

Endothelial ADGRF5(GPR116) governs vascular adaptation required for sustained thermogenic remodeling of brown adipose tissue.

Molecular metabolism·2026
Same author

Multi-omics profiling of cachexia-targeted tissues reveals a spatio-temporally coordinated response to cancer.

Nature metabolism·2026
Same journal

The interaction between inflammation and estrogen in adenomyosis : from molecular mechanisms to therapeutic strategies.

Seminars in immunopathology·2026
Same journal

The complex of gut microbial metabolites and sex hormones in Alzheimer's disease.

Seminars in immunopathology·2026
Same journal

Endometrial pathophysiology and pregnancy: from mechanism to intervention.

Seminars in immunopathology·2026
Same journal

Advances in understanding the dual roles of testicular immune responses: From immune privilege to inflammation.

Seminars in immunopathology·2026
Same journal

Climate change-associated heat extremes and immune dysregulation: emerging links with autoimmunity, allergy, and infectious diseases.

Seminars in immunopathology·2026
Same journal

The cancer-microbiome axis: Mechanisms and emerging therapeutic strategies.

Seminars in immunopathology·2026
See all related articles

Related Experiment Video

Updated: May 6, 2026

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

1.3K

Immune cells and metabolic dysfunction.

Ashley Eheim1, Dasa Medrikova, Stephan Herzig

  • 1Joint Research Division Molecular Metabolic Control, German Cancer Research Center (DKFZ), Center for Molecular Biology (ZMBH) University of Heidelberg, Network Aging Research, University Hospital Heidelberg, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

Seminars in Immunopathology
|November 12, 2013
PubMed
Summary
This summary is machine-generated.

Obesity disrupts the crucial link between immune cells and metabolism, driving inflammation and metabolic diseases. This review explores how organs like the liver impact this immunometabolic interface and potential therapies.

More Related Videos

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

24.6K
Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

36.0K

Related Experiment Videos

Last Updated: May 6, 2026

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells
06:07

Measuring Mitochondrial Function of Naïve and Effector CD8 T Cells

Published on: March 28, 2025

1.3K
Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

24.6K
Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

36.0K

Area of Science:

  • Immunometabolism
  • Obesity Research
  • Cellular Metabolism

Background:

  • Nutrient sensing and energy balance depend on immune and metabolic cell interactions.
  • Obesity perturbs this immunometabolic interface, causing chronic inflammation.
  • This inflammation is linked to metabolic disorders like insulin resistance and type 2 diabetes.

Purpose of the Study:

  • To review recent advancements in understanding the immunometabolic interface in obesity.
  • To highlight the role of metabolic organs, such as the liver, in immunometabolic control.
  • To discuss potential anti-inflammatory therapeutic strategies for obesity-related pathologies.

Main Methods:

  • Literature review of recent studies on immunometabolism and obesity.
  • Analysis of cellular and organ-level interactions in metabolic dysfunction.
  • Synthesis of findings on therapeutic interventions.

Main Results:

  • Obesity-related inflammation involves a broader range of immune cells beyond macrophages.
  • Metabolic organs, particularly the liver, significantly influence immunometabolic regulation.
  • The interplay between immune cells and metabolic organs is critical in disease development.

Conclusions:

  • The immunometabolic interface is a key target for understanding and treating obesity-related diseases.
  • Targeting organ-specific immunometabolic pathways may offer novel therapeutic avenues.
  • Further research into the liver's role in immunometabolism is crucial for developing anti-inflammatory strategies.