Related Experiment Video
Updated: May 6, 2026

05:17
Assessing Gastrointestinal Motility in Caenorhabditis elegans RAC1/CED-10 Mutants as a Tool to Study Early Parkinson's Disease
Published on: November 28, 2025
553
Very early pattern of movement disorders in sepiapterin reductase deficiency
Vincenzo Leuzzi1, Claudia Carducci, Manuela Tolve
1From the Department of Pediatrics and Child Neurology and Psychiatry (V.L., M.T.G.); Department of Experimental Medicine (Claudia Carducci, M.T., Carla Carducci); and Department of Molecular Medicine (A.A.), Sapienza Università di Roma, Rome, Italy.
Neurology
|November 12, 2013
Abstract
No abstract available in PubMed .
More Related Videos
Related Concept Videos
Parkinson Disease l: Introduction
28
Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of...
28
Huntington Disease l: Introduction
166
Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
166

