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The emerging role of TH17 cells in organ transplantation

Jeremy A Sullivan1, Andrew B Adams, William J Burlingham

  • 11 Department of Surgery, Transplant Division, University of Wisconsin, Madison, WI. 2 Department of Surgery, Emory University Medical School, Atlanta, GA. 3 Address correspondence to: William J. Burlingham, Department of Surgery, University of Wisconsin, Madison, WI.

Transplantation
|November 12, 2013
PubMed

While transplantation research continues to focus on the development of Treg-sparing and plasma cell/B-cell-targeting strategies to improve long-term outcomes, little attention has been paid to the emerging role of the TH17 cell in mediating chronic rejection. This review aimed to summarize the recent emergence of the TH17 and the newly described TH1/17 cell as major players in transplantation and to suggest ways of improving graft outcome through TH17-targeted immunosuppression.

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