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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

Clinically relevant anticancer polymer Paclitaxel therapeutics.

Danbo Yang¹, Lei Yu, Sang Van

¹Biomedical Engineering and Technology Institute, Institutes for Advanced Interdisciplinary Research, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China. yu_lei@gg.nitto.co.jp.

|November 12, 2013

Summary

This review highlights polymer-drug conjugates for cancer therapy, focusing on paclitaxel formulations. A novel poly(L-g-glutamylglutamine)-paclitaxel nano-conjugate (PGG-PTX) shows promise for improved anticancer drug delivery.

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Area of Science:

Polymer chemistry and nanomedicine
Pharmaceutical sciences
Oncology

Background:

Polymers offer versatile platforms for drug delivery, enhancing the therapeutic index of small molecule drugs.
Current polymer-based therapeutics, including polymer-drug conjugates and polymeric micelles, face challenges, with none yet approved by the FDA.
This review specifically examines clinically relevant polymer paclitaxel therapeutics for anticancer applications.

Purpose of the Study:

To review the chemistry, formulation, and clinical relevance of polymer paclitaxel therapeutics.
To evaluate in vitro activity, pharmacokinetics, tumor accumulation, in vivo efficacy, and clinical outcomes.
To introduce a novel poly(L-g-glutamylglutamine)-paclitaxel nano-conjugate (PGG-PTX) and its potential.

Main Methods:

Comprehensive literature review of polymer paclitaxel therapeutics.
Analysis of chemistry, formulation, in vitro/in vivo data, and clinical outcomes.
Presentation of data for a novel PGG-PTX nano-conjugate.

Main Results:

Polymer-drug conjugates and micelles have distinct applications requiring specific chemistry and controlled release.
The review details various polymer paclitaxel formulations, their biological activity, and clinical performance.
The novel PGG-PTX exhibits unique nanoparticle formation, favorable pharmacokinetics, and potent efficacy.

Conclusions:

Polymer-based paclitaxel therapeutics show potential for improved anticancer drug delivery.
The novel PGG-PTX nano-conjugate presents a promising candidate for future clinical development.
Further research into polymer paclitaxel therapeutics may lead to enhanced anticancer treatments.